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117830-79-2

中文名稱 人腸抑素
英文名稱 ENTEROSTATIN, HUMAN
CAS 117830-79-2
分子式 C21H36N8O6
分子量 496.56
MOL 文件 117830-79-2.mol
更新日期 2024/12/16 11:45:48
117830-79-2 結(jié)構(gòu)式 117830-79-2 結(jié)構(gòu)式

基本信息

中文別名
人腸抑素
英文別名
APGPR Enterostatin
ALA-PRO-GLY-PRO-ARG
ALA-PRO-ASP-PRO-ARG
ENTEROSTATIN, HUMAN
H-ALA-PRO-GLY-PRO-ARG-OH
L-ALA-PRO-GLY-PRO-ARG SALT
Enterostatin , mouse, rat)
H-ALA-PRO-GLY-PRO-ARG-OH ACOH
procolipase activation peptide
ENTEROSTATIN (HUMAN) ACETATE SALT

物理化學(xué)性質(zhì)

密度1.54±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度Soluble to 0.70 mg/ml in sterile water
酸度系數(shù)(pKa)3.60±0.21(Predicted)
形態(tài)凍干固體。
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3

常見(jiàn)問(wèn)題列表

生物活性
Enterostatin, human, mouse, rat是可以減少脂肪攝入量的五肽。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%).

體內(nèi)研究

Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake.

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