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117505-80-3

中文名稱 TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
英文名稱 NEUROMEDIN U (RAT)
CAS 117505-80-3
分子式 C124H180N34O31
分子量 2642.97
MOL 文件 117505-80-3.mol
更新日期 2024/12/17 14:16:28
117505-80-3 結(jié)構(gòu)式 117505-80-3 結(jié)構(gòu)式

基本信息

英文別名
NMU-23
NMU, RAT
neuromedin U
NMU-23 (RAT)
neuromedin U-23
NEUROMEDIN U (RAT)
Rat neuromedin U-23
YKVNEYQGPVAPSGGFFLFRPRN-NH2
NeuroMedin U-23 (rat) NMU-23
H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-
所屬類別
生物:小分子化合物

物理化學性質(zhì)

儲存條件−20°C
形態(tài)lyophilized powder

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany3

常見問題列表

生物活性
Neuromedin U, rat 是一種含 23 個氨基酸的腦腸肽,,通過其中樞神經(jīng)系統(tǒng)中的同源受體 NMUR2 調(diào)節(jié)幾種重要的生理功能,包括能量平衡,應(yīng)激反應(yīng)和傷害感受。
靶點

NMUR2

體外研究

To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy) 2+ 3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy) 2+ 3 -ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy) 2+ 3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection. Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy) 2+ 3 -NMU-23 to human NMUR2 receptors. From competition binding experiments, the K i values for NMU-23 is determined to be 4.7 nM.

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