1149348-10-6
中文名稱
FGI-106
英文名稱
FGI-106
CAS
1149348-10-6
分子式
C28H39ClN6
分子量
495.11
MOL 文件
1149348-10-6.mol
更新日期
2024/11/11 16:21:59
1149348-10-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11281L化合物FGI-106 TETRAHYDROCHLORIDE
英文別名
FGI-106 HClFGI-106 tetrahydrochloride
fever,pathogens,Ebola,Influenza Virus,inhibit,HIV-1,replication,HCV,hemorrhagic,Hepatitis C virus,EBOV,HIV,tetrahydrochloride,FGI106 tetrahydrochloride,Inhibitor,FGI-106 tetrahydrochloride,broad-spectrum,antiviral,Human immunodeficiency virus,lethal,FGI 106 tetrahydrochloride
常見(jiàn)問(wèn)題列表
生物活性
FGI-106 tetrahydrochloride 是一種有效的廣譜抑制劑，對(duì)多種病毒具有抑制活性。FGI-106 tetrahydrochloride 具有抗埃博拉病毒 (EBOV)，裂谷病毒 (Rift Valley virus) 和登革熱病毒 (Dengue Fever virus) 的活性，其 EC50 分別為 100 nM，800 nM 和 400-900 nM。FGI-106 tetrahydrochloride 還分別以 EC50 值為 200 nM 和 150 nM 抑制非失血性發(fā)熱病毒 HCV 和 HIV-1。靶點(diǎn)
EC50: 100 nM (Ebola virus), 800 nM (Rift Valley virus), 400-900 nM (Dengue Fever virus), 200 nM (HCV) and 150 nM (HIV-1)
體外研究
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC
90
for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.
體內(nèi)研究
FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
| Animal Model: | Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus) |
| Dosage: | 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg |
| Administration: | Intraperitoneal injection; treatments on days 2 and 5 |
| Result: | Decreased mortality from Zaire EBOV in a dose-dependent manner. |