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113658-85-8

中文名稱 113658-85-8
英文名稱 PCA 4230
CAS 113658-85-8
分子式 C21H24N2O7S
分子量 448.49
MOL 文件 113658-85-8.mol
113658-85-8 結(jié)構(gòu)式 113658-85-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13210
英文別名
PCA 4230
Trombodipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-ethyl ester

物理化學(xué)性質(zhì)

熔點144-146 °C(Solv: ethyl ether (60-29-7))
沸點623.2±65.0 °C(Predicted)
密度1.327±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.40±0.70(Predicted)

常見問題列表

生物活性
Trombodipine 是一種抗血栓劑。
體外研究

Trombodipine is an antithrombotic agent. Exposure to 50 μM Trombodipine reveals an important stasis of growth. The percentage of inhibition exerted by 1 μM Trombodipine on day 3, 5 and 7 of the growth curve is 22.0±4.5, 32.0±3.0 and 29.4±6.0%, respectively (P<0.05). The inhibitory effect of Trombodipine on cell proliferation is reversible and after removal of Trombodipine the proliferation of the cells is resumed. Addition of Trombodipine reduces cell number in a dose-dependent manner over a period of 4 to?6 days in culture. When compare to control cultures at the latest time points investigated, 5 μM Trombodipine decreases the number of E19P cells and human VSMCs by 25 and 21%, respectively, whereas 50?μM Trombodipine reduces E19P and human VSMC number by 85 and 74%, respectively.

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