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112559-91-8

中文名稱 羥基伊曲康唑(伊曲康唑代謝物)
英文名稱 HYDROXY ITRACONAZOLE
CAS 112559-91-8
分子式 C35H40Cl2N8O4
分子量 707.65
MOL 文件 112559-91-8.mol
更新日期 2024/11/15 18:20:31
112559-91-8 結(jié)構(gòu)式 112559-91-8 結(jié)構(gòu)式

基本信息

中文別名
羥基伊曲康唑
伊曲康唑雜質(zhì)1
伊曲康唑代謝物
伊曲康唑2-羥基代謝物
羥基伊曲康唑(伊曲康唑代謝物)
英文別名
R 63373
HYDROXY ITRACONAZOLE
Itraconazole Impurity 1
Itraconazole 2-Hydroxy Metabolite
Itraconazole metabolite Hydroxy Itraconazole
4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-
3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-
4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

熔點(diǎn)76-78°C
沸點(diǎn)884.7±75.0 °C(Predicted)
密度1.44±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于氯仿(少許)、乙酸乙酯(少許)、甲醇(少許)
酸度系數(shù)(pKa)14.72±0.20(Predicted)
形態(tài)固體
顏色白色至淺米色
羥基伊曲康唑(伊曲康唑代謝物)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-12772羥基伊曲康唑(伊曲康唑代謝物)
Hydroxy Itraconazole
112559-91-81mg1900元
2024/08/19HY-12772羥基伊曲康唑(伊曲康唑代謝物)
Hydroxy Itraconazole
112559-91-85mg7500元
2023/10/26HY-12772羥基伊曲康唑(伊曲康唑代謝物)
Hydroxy Itraconazole
112559-91-810mg12000元

常見問題列表

生物活性
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代謝物,Itraconazole 是一種三唑類抗真菌劑。
靶點(diǎn)

Antifungal

體外研究

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.

體內(nèi)研究

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.

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