成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>11018-89-6

11018-89-6

中文名稱 烏本( 箭毒) 苷, 哇巴因
英文名稱 OUABAIN OCTAHYDRATE
CAS 11018-89-6
分子式 C29H60O20
分子量 728.77
MOL 文件 11018-89-6.mol
更新日期 2023/03/20 17:41:23
11018-89-6 結(jié)構(gòu)式 11018-89-6 結(jié)構(gòu)式

基本信息

中文別名
烏本苷
毒毛旋花苷
十水合烏本苷
烏本苷八水合物
G毒毛旋花苷/烏本苷
烏本( 箭毒) 苷, 哇巴因
毒毛旋花苷G (羊角拗質(zhì)、烏本( 箭毒) 苷、哇巴因、烏本苷、G毒毛旋花苷、烏本苷八水合物)
英文別名
OUABAIN 8H2O
OUABAIN 8H20
G-Strophantin
STROPHANTHIN G
OUABAIN HYDRATE
OUBAIN OCTAHYDRATE
OUABAIN OCTAHYDRATE
(-)-OUABAIN OCTAHYDRATE
Ouabain octahydrate,96%
Ouabain octahydrate 96%
所屬類別
分析化學:藥典標準品和雜質(zhì)標準品

物理化學性質(zhì)

熔點260 °C
儲存條件+2C to +8C
溶解度H2O: 10 mg/mL cold
形態(tài)powder
顏色white
旋光性 (optical activity)[α]25/D 31 to 32.5° in H2O(lit.)
水溶解性易溶于水。
敏感性感光
BRN101712
穩(wěn)定性防止暴露在潮濕環(huán)境中。可在-20°C下DMSO或蒸餾水中的溶液儲存長達3個月。

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
警示詞危險
危險性描述H301+H331-H373
危險品標志T
危險類別碼23/25-33
安全說明45
危險品運輸編號UN 1544 6.1/PG 1
WGK Germany3
RTECS號RN3850000
F8
危險等級6.1(b)
包裝類別III
海關(guān)編碼29389090

應(yīng)用領(lǐng)域

用途1
Na+, K+-ATPase的典型抑制劑,抑制陽離子輸送.Cardiac glycoside.生化研究
烏本( 箭毒) 苷, 哇巴因價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/0816173八水合烏本苷
Ouabain octahydrate, 96%
11018-89-6250mg960元
2024/11/0816173八水合烏本苷
Ouabain octahydrate, 96%
11018-89-61g2018元
2024/11/0816173八水合烏本苷
Ouabain octahydrate, 96%
11018-89-65g8549元

常見問題列表

生物活性
Ouabain Octahydrate 是 Na+/K+-ATPase 抑制劑,有潛力用于充血性心力衰竭的研究。
體外研究

Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain-induced NLRP3 inflammasome activation is mediated through K + efflux. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD. Moreover, ouabain enhances migration of ADPKD cells, selectively modulates tight junctions, and modulates adherens junctions in ADPKD cells in a selective manner. Ouabain also activates TGFβ-Smad3 signaling, alters TER in ADPKD cells. Ouabain (25, 50 or 100 nM) treatment significantly reduces cell proliferation and viability in Raji cells in a dose-dependent manner, with IC 50 of 76.48±4.03 nM. Ouabain increases the number of apoptotic cells, induces autophagy, and upregulates Beclin-1 in Raji cells.

體內(nèi)研究

Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS. IL-1β deficiency attenuates ouabain-induced cardiac dysfunction and injury. IL-1β secreted by infiltrated macrophages contributes to ouabain-induced cardiac inflammation. Deficiency of NLRP3 and Casp1 attenuates ouabain-induced cardiac dysfunction and macrophage infiltration. Ouabain (30 μg/kg, i.p.) modulates ABCB1 activity in thymocytes of Wistar rats and it has the same effect on Swiss mice at 300 μg/kg. After 14 days of ouabain treatment, the MAP of rats is significantly elevated.

"11018-89-6" 相關(guān)產(chǎn)品信息
58-46-8 1223397-11-2 599-79-1 2216-51-5 2451-01-6