11018-89-6
基本信息
毒毛旋花苷
十水合烏本苷
烏本苷八水合物
G毒毛旋花苷/烏本苷
烏本( 箭毒) 苷, 哇巴因
毒毛旋花苷G (羊角拗質(zhì)、烏本( 箭毒) 苷、哇巴因、烏本苷、G毒毛旋花苷、烏本苷八水合物)
OUABAIN 8H20
G-Strophantin
STROPHANTHIN G
OUABAIN HYDRATE
OUBAIN OCTAHYDRATE
OUABAIN OCTAHYDRATE
(-)-OUABAIN OCTAHYDRATE
Ouabain octahydrate,96%
Ouabain octahydrate 96%
物理化學性質(zhì)
安全數(shù)據(jù)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | 16173 | 八水合烏本苷 Ouabain octahydrate, 96% | 11018-89-6 | 250mg | 960元 |
2024/11/08 | 16173 | 八水合烏本苷 Ouabain octahydrate, 96% | 11018-89-6 | 1g | 2018元 |
2024/11/08 | 16173 | 八水合烏本苷 Ouabain octahydrate, 96% | 11018-89-6 | 5g | 8549元 |
常見問題列表
Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain-induced NLRP3 inflammasome activation is mediated through K + efflux. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD. Moreover, ouabain enhances migration of ADPKD cells, selectively modulates tight junctions, and modulates adherens junctions in ADPKD cells in a selective manner. Ouabain also activates TGFβ-Smad3 signaling, alters TER in ADPKD cells. Ouabain (25, 50 or 100 nM) treatment significantly reduces cell proliferation and viability in Raji cells in a dose-dependent manner, with IC 50 of 76.48±4.03 nM. Ouabain increases the number of apoptotic cells, induces autophagy, and upregulates Beclin-1 in Raji cells.
Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS. IL-1β deficiency attenuates ouabain-induced cardiac dysfunction and injury. IL-1β secreted by infiltrated macrophages contributes to ouabain-induced cardiac inflammation. Deficiency of NLRP3 and Casp1 attenuates ouabain-induced cardiac dysfunction and macrophage infiltration. Ouabain (30 μg/kg, i.p.) modulates ABCB1 activity in thymocytes of Wistar rats and it has the same effect on Swiss mice at 300 μg/kg. After 14 days of ouabain treatment, the MAP of rats is significantly elevated.