106392-48-7
中文名稱
106392-48-7
英文名稱
2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
CAS
106392-48-7
分子式
C16H20N2O2
分子量
272.34
MOL 文件
106392-48-7.mol
更新日期
2024/12/23 09:08:08
106392-48-7 結(jié)構(gòu)式
基本信息
中文別名
化合物ST 271 英文別名
ST 271ST271, >98%
ST271
ST 271
ST-271
2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
物理化學(xué)性質(zhì)
沸點(diǎn)468.4±45.0 °C(Predicted)
密度1.137±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO : ≥ 110 mg/mL (403.91 mM)
酸度系數(shù)(pKa)10.05±0.40(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
ST271是一種酪氨酸磷酸化抑制劑，抑制磷脂酶D活性。靶點(diǎn)
| Target | Value |
|
PLD
() |
體外研究
ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619.