1052147-86-0
1052147-86-0 結(jié)構(gòu)式
基本信息
LP-211
LP-211 >=98% (HPLC)
LP-211
LP 211
LP211
1052147-86-0
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
物理化學(xué)性質(zhì)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-111455 | LP-211 LP-211 | 1052147-86-0 | 5mg | 800元 |
| 2024/11/08 | HY-111455 | LP-211 LP-211 | 1052147-86-0 | 10mM * 1mLin DMSO | 880元 |
| 2024/11/08 | HY-111455 | LP-211 LP-211 | 1052147-86-0 | 10mg | 1300元 |
常見(jiàn)問(wèn)題列表
|
5-HT 7 Receptor 0.58 nM (Ki) |
5-HT 1A Receptor 188 nM (Ki) |
D 2 Receptor 142 nM (Ki) |
LP-211 is a selective 5-HT 7 receptor agonist, with a K i of 0.58 nM, 324- and 245-fold selectivity over 5-HT 1A receptor (K i , 188 nM) and D 2 receptor (K i , 142 nM). LP-211 shows agonist properties with an EC 50 of 0.6 μM.
LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C max of 0.76 ± 0.32 μg/mL at 30 min. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.