1049741-55-0
1049741-55-0 結(jié)構(gòu)式
基本信息
Cardiogenol C hydrochloride(b)
2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride
4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1)
Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽 Cardiogenol C hydrochloride | 1049741-55-0 | 5mg | 600元 |
| 2024/11/08 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽 Cardiogenol C hydrochloride | 1049741-55-0 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽 Cardiogenol C hydrochloride | 1049741-55-0 | 10mg | 990元 |
常見(jiàn)問(wèn)題列表
EC50: 100 nM (differentiation of ESCs into cardiomyocytes)
Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa ) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.
RT-PCR
| Cell Line: | C2C12 cells |
| Concentration: | 0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM |
| Incubation Time: | 7 days |
| Result: | Increased ANF and NKX2.5 mRNA level as a dose-dependent manner. |
Western Blot Analysis
| Cell Line: | C2C12 cells |
| Concentration: | 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM |
| Incubation Time: | 7 days |
| Result: | Increased cardiac Nav1.5 sodium channel protein levels. |
Cell Proliferation Assay
| Cell Line: | C2C12 cells |
| Concentration: | 0.01 μM; 0.1 μM; 1 μM |
| Incubation Time: | 7 days |
| Result: | Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment. |