103898-38-0
中文名稱(chēng)
103898-38-0
英文名稱(chēng)
SM 6586
CAS
103898-38-0
分子式
C26H27N5O5
分子量
489.52
MOL 文件
103898-38-0.mol
103898-38-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16897 英文別名
SM 65863-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-[3-[[methyl(phenylmethyl)amino]methyl]-1,2,4-oxadiazol-5-yl]-4-(3-nitrophenyl)-, methyl ester
物理化學(xué)性質(zhì)
熔點(diǎn)127-128 °C
沸點(diǎn)624.0±65.0 °C(Predicted)
密度1.270±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.10±0.50(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
SM-6586 是一種 calcium channel 的拮抗劑，同時(shí)能夠抑制 Na+/H+ 和 Na+/Ca2+ exchange transport，主要用于研究腦血管疾病和高血壓等疾病。體內(nèi)研究
In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group.