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102676-31-3

中文名稱 鹽酸法倔唑
英文名稱 FADROZOLE HYDROCHLORIDE
CAS 102676-31-3
分子式 C14H13N3.ClH
分子量 259.739
MOL 文件 102676-31-3.mol
更新日期 2024/12/18 15:16:46
102676-31-3 結(jié)構(gòu)式 102676-31-3 結(jié)構(gòu)式

基本信息

中文別名
法倔唑鹽酸鹽
英文別名
CS-356
D02451
Fadrazole
CGS-16949A
Fadrozole HCl
FADROZOLE HYDROCHLORIDE
Fadrozole hydrochloride (usan)
FADROZOLE (HYDROCHLORIDE)
CGS 16949A
4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920)
+-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride

物理化學(xué)性質(zhì)

熔點(diǎn)231-233℃
儲存條件room temp
溶解度二甲基亞砜:>20mg/mL
形態(tài)粉末
顏色淡米色至淡黃色
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
警示詞危險
危險性描述H301-H361
危險品標(biāo)志Xn
危險類別碼63-22
安全說明36/37
危險品運(yùn)輸編號UN 2811 6.1 / PGIII
WGK Germany2
RTECS號DI4952500
鹽酸法倔唑價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-14247鹽酸法倔唑
Fadrozole hydrochloride
102676-31-35mg660元
2024/11/08HY-14247鹽酸法倔唑
Fadrozole hydrochloride
102676-31-310mM * 1mLin DMSO726元
2024/11/08HY-14247鹽酸法倔唑
Fadrozole hydrochloride
102676-31-310mg880元

常見問題列表

生物活性
Fadrozole hydrochloride (CGS 16949A) 是一種有效,選擇性和非甾體類的 aromatase 抑制劑,其 IC50 值為 6.4 nM。
靶點(diǎn)

IC50: 6.4 nM (aromatase)

體外研究

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC 50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.

體內(nèi)研究

Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.

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