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ChemicalBook--->CAS DataBase List--->960293-88-3

960293-88-3

960293-88-3 Structure

960293-88-3 Structure
IdentificationBack Directory
[Name]

BI605906
[CAS]

960293-88-3
[Synonyms]

CS-2032
BI605906
3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide
3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-
[Molecular Formula]

C17H22F2N4O3S2
[MDL Number]

MFCD22665698
[MOL File]

960293-88-3.mol
[Molecular Weight]

432.51
Chemical PropertiesBack Directory
[Boiling point ]

713.7±60.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Acetonitrile: 1 mg/ml; DMSO: 30 mg/ml
[form ]

A crystalline solid
[pka]

16.18±0.30(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

BI 605906, is a novel inhibitors of the kappa B kinase subunit β (IKKβ; IC50 = 380 nM).
[Biological Activity]

BI605906 is a selectiveATP-competitive IKB kinase β (IKK2IKKβIKK-beta) inhibitor (IC50 = 380 nM[ATP] = 0.1 mM) with no potency toward 100 other kinasesincluding IKKαIKKεTBK1and IGF1R (IC50 ≥7.6 μM). BI605906 (10 μM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction.
[storage]

Store at -20°C
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