| Identification | Back Directory | [Name]
DA 4643 | [CAS]
95833-19-5 | [Synonyms]
DA 4643
N-[3-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]phenyl]-N'-methylmethanimidamide | [Molecular Formula]
C12H15ClN6S | [MOL File]
95833-19-5.mol | [Molecular Weight]
310.8 |
| Hazard Information | Back Directory | [Description]
DA 4643 is one of histamine H2-receptor antagonistic. Two histamine H2-receptor antagonists of the phenylformamidine type, mifentidine (N-isopropyl-N'-(4-1H-imidazol-4-yl-phenyl) formamidine dihydrochloride; I) and DA 4643 (N-methyl-N'-(3-(2-guanidinothiazol-4-yl)-phenyl) formamidine dihydrochloride; II), have been investigated by experimental physico-chemical studies and theoretical conformational analysis. Both mifentidine and DA 4643 interact with the histamine H2-receptor at the same site, utilizing in the binding process the same, or closely similar, receptor structural features. |
|
|