| Identification | Back Directory | [Name]
NVP-LDE225 | [CAS]
956697-53-3 | [Synonyms]
CS-65
LDE225
AZP-577
Sonidegib
NVP-LDE225
Erismodegib
Sonidegib HCL
SONIDEGIB(LDE225)
LDE225 (NVP-LDE225)
NVP-LDE225 USP/EP/BP
Erismodegib (LDE225)
NVP-LDE225,Sonidegib
Sonidegib /Erismodegib
Sonidegib (NVP-LDE225)
NVP-LDE225/erisModegib
ERISMODEGIB,NVP-LDE225
LDE225 (NVP-LDE225,Sonidegib)
NVP-LDE225(LDE225,ErisModegib)
Sonidegib (LDE-225,NVP-LDE225)
Erismodegib Diphosphate,LDE225
LDE225 (NVP-LDE225,ErisModegib)
Sonidegib (Erismodegib, NVP-LDE225)
LDE225 (NVP-LDE225,ERISMODEGIB);NVP-LDE225
N-(6-((2R,6S)-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-ca
N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4,-(trifluoromethoxy)-[1,1,-biphenyl]-3-carboxamide
N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-yl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
[1,1'-Biphenyl]-3-carboxaMide, N-[6-[(2R,6S)-2,6-diMethyl-4-Morpholinyl]-3-pyridinyl]-2-Methyl-4'-(trifluoroMethoxy)-, rel-
rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide LDE225 (NVP-LDE225,Erismodegib) | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C26H26F3N3O3 | [MDL Number]
MFCD16038928 | [MOL File]
956697-53-3.mol | [Molecular Weight]
485.498 |
| Chemical Properties | Back Directory | [Melting point ]
154-157°C | [Boiling point ]
544.5±50.0 °C(Predicted) | [density ]
1.255 | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
White solid. | [pka]
9.53±0.70(Predicted) | [color ]
Light Purple |
| Hazard Information | Back Directory | [Uses]
A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. | [Definition]
ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it
phosphate salt) for treatment of locally advanced basal cell carcinoma. | [Biological Activity]
Sonidegib, also known as LDE-225, is a potent and selective smoothened (Smo) antagonist. | [target]
human Hedgehog | [storage]
Store at -20°C | [References]
[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134. |
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