| Identification | Back Directory | [Name]
TB5 | [CAS]
948841-07-4 | [Synonyms]
TB5
TB-5;TB 5
1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propene-1-one | [Molecular Formula]
C15H14BrNOS | [MDL Number]
MFCD30718167 | [MOL File]
948841-07-4.mol | [Molecular Weight]
336.25 |
| Chemical Properties | Back Directory | [Boiling point ]
468.5±45.0 °C(Predicted) | [density ]
1.440±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
4.30±0.24(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
(2E)-1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one is a monoamine oxidase B (MAO-B) inhibitor. Monoamine oxidase B is involved in the metabolism of dopamine. Mao-B inhibitors are potential compounds used to treat Parkinson's disease. | [Biological Activity]
TB5 is a potent and selective reversible inhibitor of monoamine oxidase B (MAOB) with a Ki value of 110 nM. A reversible inhibitor should have an advantage over irreversible inhibitors such as selegiline in limiting side effects. Parallel artificial membrane permeation (PAMPA) assays indicated TB5 should be able to cross the blood–brain barrier. TB5 was found nontoxic to cells. |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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