| Identification | Back Directory | [Name]
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide | [CAS]
947303-87-9 | [Synonyms]
CS-122
PF 429242
-4-((Diethylamino)
PF-429242;PF429242
-N-(pyrrolidin-3-yl)
-N-(2-methoxyphenethyl)
PF-429242 dihydrochloride
PF-429242 (hydrochloride)
4-((diethylaMino)Methyl)-N-(2-Methoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide
o)Meth (2-MetR)-4-((diethylaMinyl)-Nhoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide
(R)-4-((DiethylaMino)Methyl)-N-(2-Methoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide
Benzamide, 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-
(R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide dihydrochloride
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride | [Molecular Formula]
C25H35N3O2 | [MDL Number]
MFCD21603814 | [MOL File]
947303-87-9.mol | [Molecular Weight]
409.56 |
| Chemical Properties | Back Directory | [Boiling point ]
562.2±50.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
H2O: soluble15mg/mL, clear | [form ]
powder | [pka]
9.47±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 15mg/mL, clear | [InChIKey]
XKPJTOHUPQWSOJ-HSZRJFAPSA-N |
| Hazard Information | Back Directory | [Uses]
PF 429242 is a novel subtilisin kexin isozyme-1/site-1 (SKI-1/S1P) protease inhibitor. PF 429242 is a sterol regulatory element-binding protein1 (SREBP1) inhibitor and has been shown to decrease pancreatic cancer cell viability and proliferation. | [Biochem/physiol Actions]
PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV. | [storage]
Store at -20°C |
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