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ChemicalBook--->CAS DataBase List--->940290-58-4

940290-58-4

940290-58-4 Structure

940290-58-4 Structure
IdentificationBack Directory
[Name]

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide
[CAS]

940290-58-4
[Synonyms]

4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide
[EINECS(EC#)]

685-053-3
[Molecular Formula]

C17H13N3O2
[MOL File]

940290-58-4.mol
[Molecular Weight]

291.304
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS09
[Signal word ]

Warning
[Hazard statements ]

H302-H400
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P273-P391-P501
Hazard InformationBack Directory
[Biological Activity]

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1]. UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1]. UK122 (10-100 μM; 48 h) has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].
[References]

[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.
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