| Identification | Back Directory | [Name]
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT | [CAS]
93882-12-3 | [Synonyms]
pcpt-camp
8-CPT-CAMP, NA
8-PCPT-CAMP NA
CAMP, 8-PCPT-, NA
8-CPT-CAMP SODIUM SALT
8-CPT-Cyclic AMP (sodium salt)
8-(4-CHLOROPHENYLTHIO)-CAMP SODIUM
8-(4-CHLOROPHENYLTHIO)ADENOSINE 3':5'-CY CLIC MONOP
8-[(4-Chlorophenyl)thio]adenosine 3',5'-phosphoric acid sodium salt
8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
8-[(4-CHLOROPHENYL)THIO]-ADENOSINE CYCLIC 3',5'-HYDROGEN PHOSPHATE SODIUM
ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-(4-CHLOROPHENYLTHIO)-, SODIUM SALT
8-(4-Chlorophenylthio)adenosine 3',5'-(Cyclic)monophospphate Sodium Salt
8-(4-Chlorophenylthio)-adenosine-3'',5''-cyclic monophosphoric acid sodium sa
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphate(8-cpt-camp),sodiumsalt
8-(4-Chlorophenylthio)adenosine 3',5'-(Cyclic)monophosphate Sodium Salt, 98.0+ % (HPLC)
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate), monosodium salt
Adenosine 3,5-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem | [EINECS(EC#)]
299-413-9 | [Molecular Formula]
C16H14ClN5NaO6PS | [MDL Number]
MFCD00057683 | [MOL File]
93882-12-3.mol | [Molecular Weight]
493.79 |
| Hazard Information | Back Directory | [Uses]
8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:
- to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1)
- in glucose production assay
- to stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia
| [Uses]
8-CPT-cAMP is an efficient activator of cGK and cAMP-PK, and inhibitor of PDE. | [General Description]
Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 μM). | [Biological Activity]
ka : 0.05 and 0.11 μm for pka and pkg, respectively8-cpt-cyclic amp is a lipophilic activator of the cyclic-amp- and cyclic-gmp-dependent protein kinases, pka and pkg.the ability of cgmp-dependent protein kinases (cgks) to activate camp response element (cre)-dependent gene transcription was compared with that of camp-dependent protein kinases (caks). | [Biochem/physiol Actions]
Cell permeable: yes | [in vitro]
a previous study found that 8-cpt-cyclic amp was a potent activator of camp-pk and cyclic-gmp-dependent protein kinase (cgmp-pk) both as purified enzymes and in platelet membranes. 8-cpt-cyclic amp was hydrolysed to a significant extent by the ca2+/calmodulin-dependent phosphodiesterase and by the cgmp-inhibited phosphodiesterase. moreover, sp-5,6- dcl-cbimps was also more effective than 8-cpt-cyclic amp in inducing quantitative phosphorylation of vasodilator-stimulated phosphoprotein in intact platelets [1]. another study indicated that 8-cpt-cyclic amp was a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). indeed, 8-cpt-cyclic amp could inhibit pde va with a potency similar to that of zaprinast. in addition, 8-cpt-cyclic amp was metabolized by pde va at a rate half that of cyclic gmp. the cyclic gmp-inhibited phosphodiesterase and the cyclic amp-specific phosphodiesterase could be inhibited by 8-cpt-cyclic amp as well [2]. | [storage]
Store at -20°C | [References]
[1] sandberg, m. ,butt, e.,nolte, c., et al. characterization of sp-5,6-dichloro-1-β-d-ribofuranosylbenzimidazole-3',5'-monophosphorothioate (sp-5,6-dcl-cbimps) as a potent and specific activator of cyclic-amp-dependent protein kinase in cell extracts and intact cells. biochemistry journal 279, 521-527 (1991).
[2] connolly, b. j.,willits, p.b.,warrington, b.h., et al. 8-(4-chlorophenyl)thio-cyclic amp is a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). biochemical pharmacology 44(12), 2303-2306 (1992). |
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