| Identification | Back Directory | [Name]
Casein Kinase II Inhibitor III | [CAS]
934358-00-6 | [Synonyms]
TBCA
Tetrabromocinnamic acid
SVJQCVOKYJWUBC-OWOJBTEDSA-N
Casein Kinase II Inhibitor III
Casein Kinase II Inhibitor III, TBCA
(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid
InSolution? Casein Kinase II Inhibitor III, TBCA
(2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic acid
2-Propenoic acid, 3-(2,3,4,5-tetrabromophenyl)-, (2E)-
Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem
InSolution Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem | [Molecular Formula]
C9H4Br4O2 | [MDL Number]
MFCD20921901 | [MOL File]
934358-00-6.mol | [Molecular Weight]
463.74 |
| Chemical Properties | Back Directory | [Melting point ]
189.2-191.2 °C | [Boiling point ]
490.8±45.0 °C(Predicted) | [density ]
2.443±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
3.83±0.16(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Casein Kinase II Inhibitor III is a casein kinase 2 inhibitor. A protein kinase inhibitors used to elucidate cellular signaling pathways.
| [Biological Activity]
tetrabromocinnamic acid (tbca) is a new class of specific protein kinase ck2 inhibitors [1].protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. the ser/thr-specific protein kinase ck2 has been implicated in signal transduction, gene expression, dna repair, rna and protein synthesis. ck2 is invariably elevated in a wide spectrum of tumours [1]. | [in vitro]
tbca was a selective, cell-permeable inhibitor of ck2 with an ic50 of 0.11 μm. the ki value was 77 nm. tbca showed minimal effect on a panel of 28 other kinases. tbca induced cell death in jurkat adult t cell leukemia cells with an dc50 of 7.7 μm [1]. tbca dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-mesadp, aypgkf, sfllrn, and crp [2]. tbca also significantly inhibited agonist-induced thromboxane a2 (txa2) generation and erk phosphorylation. tbca significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αiibβ3 signaling [2]. | [storage]
Store at -20°C | [References]
[1] pagano m a, poletto g, di maira g, et al. tetrabromocinnamic acid (tbca) and related compounds represent a new class of specific protein kinase ck2 inhibitors[j]. chembiochem, 2007, 8(1): 129-139.
[2] ryu s y, kim s. evaluation of ck2 inhibitor (e)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (tbca) in regulation of platelet function[j]. european journal of pharmacology, 2013, 720(1): 391-400. |
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