| Identification | Back Directory | [Name]
EC 1.6.4.2 | [CAS]
9001-48-3 | [Synonyms]
GR
GR TYPE II
GR TYPE VI
EC 1.8.1.7
EC 1.6.4.2
EC: 1.6.4.2
E.C. 1.8.1.7
GSH reductase
GSSG reductase
NADPH-GSSG reductase
GLUTATHIONE REDUCTASE
Reductase, glutathione
Glutathione S-reductase
NADPH-glutathione reductase
Glutathionereductaseexyeast
GLUTATHIONE REDUCTASE, YEAST
GLUTATHIONE REDUCTASE TYPE II
GLUTATHIONE REDUCTASE TYPE VI
Glutathione Reductase human
glutathione reductase from spinach
Glutathione disulfide oxidoreductase
NADP-dependent glutathione reductase
Native Spinach Glutathione Reductase
Glutathione Reductase, from Yeast[GR]
glutathione reductase from wheat germ
Native Wheat germ Glutathione Reductase
GLUTATHIONE REDUCTASE FROM BAKER'S &
GlutathioneReductaseExYeast(E.C.1.6.4.2)
glutathione reductase from baker'S yeast
Glutathionereductase, 189units/mg protein
GLUTATHIONE REDUCTASE TYPE VI FROM*SPINA CH
GR/Glutathione Reductase froM baker's yeast
NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE
Glutathione Reductase from Human, Recombinant
Glutathione reductase from E. coli, Recombinant
GR, (NAD(P)H): oxidized-glutathione oxidoreductase
Glutathione Reductase bakers yeast (S. cerevisiae)
GLUTATHIONE REDUCTASE TYPE II CRUDE*FROM WHEAT GERM
GLUTATHIONE REDUCTASE FROM BAKER'S YEAST , ~100 U/MG
NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE II
NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE VI
glutathione reductase from baker's yeast (s. cerevisiae)
Glutathione Reductase from bovine intestinal mucosa
Native Bakers yeast (S. cerevisiae) Glutathione Reductase
Glutathione reductase (NAD(P)H) from Yeast, 50% glycerol solution
Glutathione Reductase from spinach,GR, NAD(P)H: oxidized-glutathione oxidoreductase
Glutathione Reductase from baker's yeast (S. cerevisiae),GR, NAD(P)H:oxidized-glutathione oxidoreductase | [EINECS(EC#)]
232-608-9 | [Molecular Formula]
NULL | [MDL Number]
MFCD00131196 |
| Hazard Information | Back Directory | [Uses]
Human glutathione reductase has been used in:
- glutathione reductase activity assay
- oxidative stress analysis
- redox assays
| [General Description]
Glutathione reductase (GLR1) exists in mitochondrial and cytoplasmic isoforms. It shares sequence and structural homology to thioredoxin reductase, and is a flavin-containing oxidoreductase. Its active site is composed of a redox-active disulphide, and it requires NADPH for its catalytic activity. It is a widely present enzyme and is found in plants, bacteria, yeast, mice and humans. | [Biochem/physiol Actions]
Glutathione reductase IGR) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems. |
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