| Identification | Back Directory | [Name]
3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC A& | [CAS]
889940-13-0 | [Synonyms]
3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC
3,3-Trifluoro-2,2-diMethylpropionic acid
3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC A&
3,3,3-Trifluoro-2,2-dimethylpropionic acid
3,3,3-trifluoro-2,2-dimethylpropanoic acid
2-(trifluoromethyl)-2-methylpropanoic acid
Propanoic acid, 3,3,3-trifluoro-2,2-diMethyl-
3,3,3-Trifluoro-2,2-dimethylpropionic acid 97% | [Molecular Formula]
C5H7F3O2 | [MDL Number]
MFCD08445819 | [MOL File]
889940-13-0.mol | [Molecular Weight]
156.102 |
| Chemical Properties | Back Directory | [Melting point ]
66-71 °C | [Boiling point ]
76-77°C/14mm | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C5H7F3O2/c1-4(2,3(9)10)5(6,7)8/h1-2H3,(H,9,10) | [InChIKey]
VMFSJVUPIXOCFO-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C(C)(C)C(F)(F)F | [CAS DataBase Reference]
889940-13-0 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26 | [RIDADR ]
3261 | [WGK Germany ]
3 | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Uses]
3,3,3-Trifluoro-2,2-dimethylpropanoic Acid, is an organic buliding blocks, that can be used in the synthesis of variety of pharmaceutical compounds, such as inhibitors. | [Synthesis]
Prepare a dry, clean 1L four-necked flask. 18g of 3,3,3-trifluoro-2,2-dimethylpropanenitrile was added to it, and 500 ml of a 5 mol/L sodium hydroxide aqueous solution was placed in the flask; stir well; the mixture was heated to a temperature of 90-100 ° C and refluxed overnight. The reaction was terminated until 3,3,3-trifluoro-2,2-dimethylpropanenitrile was completely reacted. Concentrated hydrochloric acid was used to adjust the pH to 1. Continue stirring for 30 minutes, Extracted with 50*3ml of dichloromethane; the organic layers were combined and concentrated to give a white solid (3,3,3-Trifluoro-2,2-dimethylpropionic acid). The yield was 84.3% (GC 98%).
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