| Identification | Back Directory | [Name]
M 8218 | [CAS]
87827-02-9 | [Synonyms]
M 8218
BENC-003
Penehyclidine
Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-
benzeneMethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)Methyl]-a-cyclopentyl- hydrochloride | [Molecular Formula]
C20H30ClNO2 | [MDL Number]
MFCD27977255 | [MOL File]
87827-02-9.mol | [Molecular Weight]
351.911 |
| Hazard Information | Back Directory | [Uses]
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2]. | [IC 50]
mAChR1; mAChR3; NF-κB | [References]
[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. DOI:10.2147/DDDT.S36555 |
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