| Identification | Back Directory | [Name]
(6aR,10aR)-3-(6-imidazol-1-yl-2-methylhexan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol:hydrochloride | [CAS]
874745-43-4 | [Synonyms]
(6aR,10aR)-3-(6-imidazol-1-yl-2-methylhexan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol:hydrochloride | [Molecular Formula]
C26H37ClN2O2 | [MOL File]
874745-43-4.mol | [Molecular Weight]
445.04 |
| Hazard Information | Back Directory | [Description]
Cannabinoid agonists are typically highly lipophilic compounds that require solubilization with either a surfactant agent or adherence to a water miscible substance such as albumin, Tween 80, or Emulphor. O-2545 is a potent water-soluble agonist of central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 1.5 and 0.32 nM, respectively.1 When dissolved in saline, O-2545 was highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly.1 | [References]
1. Martin, B.R., Wiley, J.L., Beletskaya, I., et al. Pharmacological characterization of novel water-soluble cannabinoids J. Pharmacol. Exp. Ther. 318,1230-1239(2006). |
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