| Identification | Back Directory | [Name]
Unii-p9vxv1408y | [CAS]
866021-48-9 | [Synonyms]
4-[2-[[(6R
Ceftaroline
Unii-p9vxv1408y
Ceftarolin Fosamil
Ceftaroline Impurity8
Ceftaroline USP/EP/BP
Unii-p9vxv1408y USP/EP/BP
Ceftaroline Fosamil Acetate Hydrate
7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1
acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)
4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydrate
acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,hydrate | [MDL Number]
MFCD19443689 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Ceftaroline fosamil acetate monohydrate is a hydrate that is the monohydrate form of ceftaroline fosamil acetate. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections. It has a role as an antimicrobial agent, an antibacterial drug and a prodrug. It contains a ceftaroline fosamil acetate. | [Antimicrobial activity]
A semisynthetic cephalosporin formulated as the water-soluble
fosamil acetate prodrug for intravenous administration.
Its properties are similar to those of ceftobiprole, with
which it shares an enhanced affinity for penicillin-binding
protein 2′ (2a) of methicillin-resistant Staph. aureus.
It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative
bacilli. | [Pharmacokinetics]
Cmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion
Plasma half-life: 2.6 h
Volume of distribution: 0.37 L/kg
Plasma protein binding :<20%
Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in
plasma after intravenous infusion and excreted principally in urine.
In preliminary clinical studies it appears to be well tolerated. |
|
|