Identification | Back Directory | [Name]
4SC-201 | [CAS]
864814-88-0 | [Synonyms]
CS-304 4SC-201 RAS2410 ResMinostat ResMinostat(4SC-201) ResMinostat (RAS2410) RESMINOSTAT; 4SC-201; RAS2410 4SC-201(resminostat,BYK408740) RAS2410;4SC-201;RAS 2410;RAS-2410 (E)-3-[1-[4-[(dimethylamino)methyl]phenyl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide (E)-3-(1-((4-((Dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide (E)-3-[1-[[4-[(Dimethylamino)methyl]benzene]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxyacrylamide 2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, (2E)- (E)-3-[1-[[4-[(Dimethylamino)methyl]benzene]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxyacrylamide Resminostat | [Molecular Formula]
C16H19N3O4S | [MDL Number]
MFCD18633257 | [MOL File]
864814-88-0.mol | [Molecular Weight]
349.4 |
Hazard Information | Back Directory | [Uses]
Resminostat is an oral histone deacetylase (HDAC) inhibitor. It inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. | [Biological Activity]
resminostat, also known as ras2410, is a potent inhibitor of histone deacetylase (hdac) classes i and ii (including hdac1, hdac3 and hdac6) with 50% inhibition concentration ic50 values ranging from 43 to 72 nmol/l. resminostate has the potential to be used for the treatment of multiple myeloma (mm) due to its ability to induce histone h4 hyperacetylation, and apoptosis (ic50 ranging from 2.5 to 3 μmol/l) in mm cells. recent study results have shown that, in mm cell lines, resminostat abrogates cell growth, suppresses proliferation and induce g0/g1 cell cycle arrest as well as interfering with akt signaling pathway by decreasing phosphorylation of 4e-bp1 and p70s6k.mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010; 149(4):518-528. | [storage]
Store at -20°C |
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NCE Biomedical Co.,Ltd.
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