| Identification | Back Directory | [Name]
2'-deoxy-2'-fluoro-2'-C-methyluridine | [CAS]
863329-66-2 | [Synonyms]
CS-832
RO 2433
PSI-6206
9-(2'
1-(2'
GS-331007
PSI 6206 int
-deoxy-2'
7-Deaza-2'
-fluoroguanosine
-C-methyluridine
Sofosbuvir INT 1
Sofosbuvir imp-11
2-Fluoro-9-(2'
PSI-6206 (RO 2433)
-C-ethynyladenosine
N4-Benzoyl-1-(2'
Sofosbuvir int. N-1
-deoxy-7-iodoadenosine
-deoxy-7-iodoguanosine
-deoxy-7-ethynyladenosine
-deoxy-O6-methylguanosine
-deoxy-6-methoxyguanosine
Sofosbuvir Intermediate 4
Sofosbuvir Intermediates 2
-(Methoxycarbonyl)[1,1'
-(Aminoiminomethyl)[1,1'
PSI-6206 (RO-2433, GS-331007)
dcoxy-2-fuoro-2-C-methyhurdine
Sofosbuvir Metabolite GS331007
2'-Deoxy-2'-F-2'-C-methyluridine
-fluoro-b-D-ribofuranosyl)purine
2'-Deoxy-2-floro-2'Methyl-uridine
PSI-6206; RO-2433; PSI6206; RO2433
-fluoro-b-D-arabinofuranosyl)purine
2'-deoxy-2'-fluoro-2'-methyluridine
-O-trityl-b-L-lyxofuranosyl)-uracil
-fluoro-b-D-arabinofuranosyl)guanine
-fluoro-b-D-arabinofuranosyl)adenine
-fluoro-b-L-arabinofuranosyl)-uracil
-chloro-b-L-arabinofuranosyl)-thymine
-fluoro-b-D-arabinofuranosyl)cytosine
-fluoro-b-D-ribofuranosyl)-isoguanine
2'-deoxy-2'-fluoro-2'-C-methyluridine
-fluoro-a-L-arabinofuranosyl)-thymine
-O-trityl-b-L-arabinofuranosyl)-uracil
-fluoro-b-D-arabinofuranosyl)hypoxantine
β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
-fluoro-b-D-arabinofuranosyl)cytosine HCl
-fluoro-b-D-arabinofuranosyl)uracil 3'
-fluoro-b-D-arabinofuranosyl)-5-iodouracil
-O-4-C-Methylene-b-D-ribofuranosyl)thymine
-fluoro-b-D-arabinofuranosyl)thymine 3'
-fluoro-b-D-ribofuranosyl)-2-fluoroadenine
(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
2'-deoxy-2'-fluoro-2'-C-Methyluridine (N-1)
-fluoro-b-D-arabinofuranosyl)-5-ethyluracil
5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine
Sofosbuvir Nucleoside Derivative (GS-331007)
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine>
Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-
-fluoro-beta-d-arabinofuranosyl)-5-ethyluracil
-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'
-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1)
2'-DEOXY-2'-FLUORO-2'-C-METHYLURIDINE,CAS 863329-66-2
Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206
-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'
2'-deoxy-2'-fluoro-2'-C-methyluridine ISO 9001：2015 REACH
-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid
-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5
-biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester
-biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester
-biphenyl]-4-yl]methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester
1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione
1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433 | [EINECS(EC#)]
810-481-6 | [Molecular Formula]
C10H13FN2O5 | [MDL Number]
MFCD19982668 | [MOL File]
863329-66-2.mol | [Molecular Weight]
260.219 |
| Chemical Properties | Back Directory | [Melting point ]
237-238℃ | [density ]
1.55 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
9.39±0.10(Predicted) | [color ]
White to Light Beige |
| Hazard Information | Back Directory | [Description]
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase. | [Uses]
RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro. | [Biological Activity]
psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820 | [target]
HCV |
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