| Identification | Back Directory | [Name]
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE | [CAS]
86030-08-2 | [Synonyms]
BTB-1
NSC156750
BTB 1; BTB1
LABOTEST-BB LT01147747
BTB 1 - NSC 156750 | NSC 658180
4-CHLORO-2-NITRODIPHENYL SULFONE
4-Chloro-2-nitrodiphenyl sulphone
1-Benzenesulfonyl-4-chloro-2-nitro-benzene
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
4-chloro-2-nitro-1-(phenylsulphonyl)benzene
Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)-
1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid | [Molecular Formula]
C12H8ClNO4S | [MDL Number]
MFCD00052250 | [MOL File]
86030-08-2.mol | [Molecular Weight]
297.71 |
| Chemical Properties | Back Directory | [Melting point ]
115 °C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO (30 mg/ml) | [form ]
solid | [color ]
White to off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5 | [Uses]
BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A. | [storage]
Store at +4°C | [References]
Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072
Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554
Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539
Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41
Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463 |
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DC Chemicals
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021-58447131 13564518121 |
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http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
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