| Identification | Back Directory | [Name]
Asenapine Maleate | [CAS]
85650-56-2 | [Synonyms]
Org 5222
Asenne maleate
Unii-cu9463U2E2
Org5222 Maleate
Saphris Maleate
Org 5222 Maleate
Org-5222 Maleate
Einecs 288-064-8
Asenapine maleate
Asenapine maleate solution
Asenapine Maleate USP/EP/BP
Asenapine maleate, racemic mixture
Asenapine maleate, 98%, a 5-HT receptor antagonist
SAPHRIS MALEATE; ORG 5222 MALEATE; ORG-5222 MALEATE; ORG5222 MALEATE
H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aS,12bS)-
trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, trans-, (Z)-2-butenedioate (1:1) | [EINECS(EC#)]
288-064-8 | [Molecular Formula]
C21H20ClNO5 | [MDL Number]
MFCD00900588 | [MOL File]
85650-56-2.mol | [Molecular Weight]
401.84 |
| Chemical Properties | Back Directory | [Melting point ]
141-145° | [Fp ]
9℃ | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥10mg/mL | [form ]
powder | [pka]
pK1 <3, pK2 7.52, pK3 8.51(at 25℃) | [color ]
white to off-white | [Water Solubility ]
Water : 6.25 mg/mL (15.55 mM; Need ultrasonic and warming) | [InChIKey]
GMDCDXMAFMEDAG-CHHFXETESA-N |
| Hazard Information | Back Directory | [Description]
Asenapine, a dual antagonist of dopamine D2and serotonin 5-HT2receptors, was launched for the acute treatment of schizophreniaand manic or mixed episodes associated with bipolar I disorder in adults. Asenapine exhibits high affinity for serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors (Ki = 2.5, 4.0, 0.06, 0.16, 0.03, 1.6, 0.25, and 0.13 nM, respectively); dopamine D1, D2, D3, and D4 receptors (Ki = 1.4, 0.42, 1.1, and 1.3 nM, respectively); a1- and a2-adrenergic receptors (Ki = 1.2 and 1.2 nM, respectively); and histamine H1 receptors (Ki = 1.0 nM), and moderate affinity for H2 receptors (Ki = 6.2 nM). In in vitro assays, asenapine acts as an antagonist at these receptors. Asenapine has no appreciable affinity for muscarinic cholinergic receptors (e.g., Ki = 8128 nM for M1). Despite its potent binding affinity for multiple receptors, the efficacy of asenapine in schizophrenia is thought to be primarily mediated through a combination of antagonist activity at D2 and 5-HT2A receptors. | [Chemical Properties]
White Solid | [Originator]
Organon (US) | [Uses]
Antipsychotic;serotonin 5-HT receptors | [Uses]
Asenapine Maleate is a 5-HT receptor antagonist developed for the treatment of acute schizophrenia and bipolar mania. | [Definition]
ChEBI: (S,S)-asenapine maleate is a maleate salt obtained by combining equimolar amounts of (S,S)-asenapine and maleic acid. It contains a (S,S)-asenapine(1+). It is an enantiomer of a (R,R)-asenapine maleate. | [Brand name]
Saphris | [General Description]
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. The drug is marketed under the trade names Saphris? and Sycrest. This certified solution standard is suitable for LC/MS or GC/MS applications in clinical toxicology, forensic testing, or pharmaceutical research. | [Biochem/physiol Actions]
Asenapine maleate is a 5-HT receptor antagonist (5-HT1A,1B, 5-HT2A, 2B, 2C, 5-HT5A, 5-HT6 and 5-HT7), a D2 antagonist, and an antipsychotic. | [Side effects]
The most common adverse effects associated with asenapine treatment include insomnia, somnolence, nausea, anxiety, agitation, headache, vomiting, constipation, and psychosis. In placebo-controlled trials with risperidone, aripiprazole, and olanzapine in elderly subjects with dementia, there was a higher incidence of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) including fatalities compared to placebo-treated subjects. Asenapine is not approved for the treatment of patients with dementia-related psychosis. | [Synthesis]
The chemical synthesis of asenapine can be achieved by several different methods. A concise synthesis of asenapine begins with the Horner-Emmons condensation of diethyl (5-chloro-2-fluoro)benzyl phosphonate with salicylaldehyde to produce the corresponding stilbene derivative, which undergoes a 1,3-dipolar cycloaddition reaction with trimethylamine-N-oxide in the presence of lithium diisopropylamide to furnish a trans-3,4-diarylpyrrolidine intermediate. Then, a base-catalyzed intramolecular cyclization involving the nucleophilic displacement of the fluoro group by the phenolic hydroxyl group affords asenapine, which
is finally treated with maleic acid in ethanol to yield the corresponding
maleate salt. | [storage]
4°C, away from moisture |
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