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ChemicalBook--->CAS DataBase List--->852045-46-6

852045-46-6

852045-46-6 Structure

852045-46-6 Structure
IdentificationBack Directory
[Name]

FLT3 Inhibitor III
[CAS]

852045-46-6
[Synonyms]

MDK5466
MDK-5466
MDK 5466
Flt3-IN-III
FLT3 Inhibitor III
[Molecular Formula]

C21H23N3OS
[MDL Number]

MFCD24369051
[MOL File]

852045-46-6.mol
[Molecular Weight]

365.49
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml; Ethanol: 20 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

FLT3 Inhibitor III is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3; IC50 = 50 nM). It shows high selectivity for FLT3 over a panel of 300 other kinases. FLT3 Inhibitor III blocks FLT-dependent cell proliferation in a dose-dependent manner. FLT3 Inhibitor III has been used to study signaling through FLT3 and FLT3 with internal tandem duplications (FLT3-ITD) in cells.
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