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ChemicalBook--->CAS DataBase List--->851814-28-3

851814-28-3

851814-28-3 Structure

851814-28-3 Structure
IdentificationBack Directory
[Name]

PIAA
[CAS]

851814-28-3
[Synonyms]

PIAA
2-Propenoic acid, 3-(3-phenyl-2,1-benzisoxazol-5-yl)-
[Molecular Formula]

C16H11NO3
[MDL Number]

MFCD06386715
[MOL File]

851814-28-3.mol
[Molecular Weight]

265.26
Chemical PropertiesBack Directory
[Boiling point ]

511.9±35.0 °C(Predicted)
[density ]

1.323±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear (warmed)
[form ]

powder
[pka]

4.08±0.50(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Definition]

ChEBI: 3-(3-phenyl-2,1-benzoxazol-5-yl)-2-propenoic acid is a member of cinnamic acids.
[Biological Activity]

PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) th at has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity
851814-28-3 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Website: http://www.synzest.com
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