| Identification | Back Directory | [Name]
OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER | [CAS]
843666-40-0 | [Synonyms]
18-(tert-Butoxy)
mono-t-Butyl stearate
-18-oxooctadecanoic acid
Mono-tert-butyl Octadecanedioate
tert-butyl 17-carboxyheptadecanoate
tert-Butyl Hydrogen Octadecanedioate
Octadecanedioic acid mono-t-butyl ester
Octadecanedioic acid 1-tert-butyl ester
18-(tert-Butoxy)-18-oxooctadecanoic acid
OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER
Octadecanedioic acid,1-(1,1-dimethylethyl) ester
Octadecanedioic acid mono(1,1-dimethylethyl) ester
18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
18-(tert-Butoxy)-18-oxostearic acid, tert-Butyl 17-carboxyheptadecanoate | [Molecular Formula]
C22H42O4 | [MDL Number]
MFCD09991735 | [MOL File]
843666-40-0.mol | [Molecular Weight]
370.58 |
| Questions And Answer | Back Directory | [Appearance]
White to Almost white powder to crystal | [Detection Method]
Octadecanedioic acid mono-tert-butyl ester (18-(tert-Butoxy)-18-oxooctadecanoic Acid) is a preparation raw material of the side chain of the somaglutide. The technical scheme is that a purchased raw material with the main component of octadecanedioic acid mono-tert-butyl ester is detected, whether the purity of the raw material substance is within a quality control standard or not is verified, and the purpose of detecting the purity of the raw material substance is to ensure the synthesis yield of a finished product of the side chain of the later-stage somnautide. For process reasons, raw materials usually comprise impurities such as octadecanedioic acid, tetradecanedioic acid mono-tert-butyl ester, hexadecanedioic acid mono-tert-butyl ester, octadecanedioic acid mono-methyl ester and octadecanedioic acid mono-methyl ester, and the current detection method mainly bases on the general rule of the four departments of the 2015 version of Chinese pharmacopoeia, but no method for separately detecting the octadecanedioic acid mono-tert-butyl ester exists, and the product is a long-chain alkane series, has long retention time in a chromatographic column and is difficult to elute in a proper time. A method for testing octadecane dioic acid mono-tert-butyl ester comprises the following steps: S1. preparing a test solution and a system suitability solution; S2. using high performance liquid chromatography for detection, the chromatographic conditions comprising: using Agilent ZORBAX SB-C18 as a chromatographic column, using 0.1% phosphoric acid aqueous solution as mobile phase A, using acetonitrile as mobile phase B, performing gradient elution, the column temperature being 35°C, the flow rate being 1.0 mL/min, and the detection wavelength being 210 nm; S3. calculating the purity of the test sample by the area normalization method, and observing the sizes of known impurities and other unknown impurities in the chromatogram.
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| Chemical Properties | Back Directory | [Melting point ]
68 °C | [Boiling point ]
470.7±18.0 °C(Predicted) | [density ]
0.950±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.78±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Octadecanedioic acid mono-tert-butyl ester(843666-40-0) is a non-cleavable ADC linker or alkyl chain-based PROTAC linker for the synthesis of antibody-drug couplings (ADCs) and PROTACs.
| [Uses]
18-(tert-Butoxy)-18-oxooctadecanoic Acid(843666-40-0) is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.
| [Application]
18-(tert-Butoxy)-18-oxooctadecanoic Acid(843666-40-0) is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.
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