| Identification | Back Directory | [Name]
Trimeprazine | [CAS]
84-96-8 | [Synonyms]
Teralen
Teralene
Alimezine
Bayer 1219
ALIMENAZINE
alimemazine
TRIMEPRAZINE
Trimeperazine
Methylpromazine
dl-Trimeprazine
Trimeprazine USP/EP/BP
Alimemazine-d6 MALEATE SALT
Trimeprazine (base and/or unspecified salts)
10H-Phenothiazine-10-propanaMine,N,N,b-triMethyl-
10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-
10-[2-Methyl-3-(dimethylamino)propyl]phenothiazine
10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine
n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)amine
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-
10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine
N,N,2-triMethyl-3-(10H-phenothiazin-10-yl)propan-1-aMine
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]- (6CI, 8CI) | [EINECS(EC#)]
201-577-3 | [Molecular Formula]
C18H22N2S | [MDL Number]
MFCD00242597 | [MOL File]
84-96-8.mol | [Molecular Weight]
298.45 |
| Hazard Information | Back Directory | [Originator]
Temaril,SKF,US,1958 | [Uses]
antipruritic | [Uses]
Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic
origin. | [Definition]
ChEBI:Trimeprazine is a member of phenothiazines. | [Manufacturing Process]
95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in
xylene is then added over 50 minutes and heating with reflux is continued for
20 hours. After cooling, the mixture is treated with water (40 cc) and N
methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated
with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with
ether.
The extract is dried over potassium carbonate and evaporated and the residue
is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane
(12.6 grams) is collected, distilling between 150° and 175°C under a pressure
of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal
hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C. | [Brand name]
Temaril (Allergan). | [Therapeutic Function]
Antipruritic |
|
| Company Name: |
Ralington Pharma
|
| Tel: |
+91-7948911722 +91-9687771722 |
| Website: |
www.ralingtonpharma.com |
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|