| Identification | Back Directory | [Name]
DIENESTROL | [CAS]
84-17-3 | [Synonyms]
DV
Dinovex
Agaldog
Restrol
Retalon
Sexadien
Teserene
Oestrora
Estroral
Follormon
Dinestrol
Oestrasid
Estragard
Oestroral
Oestrovis
para-Dien
Estraguard
Gynefollin
Hormofemin
DIENESTROL
CYCLADIENE
Oestrodiene
Estrodienol
Dienesterol
Dienoestrol
Willnestrol
Oestrodienol
Dienoestrol bp
Dienestrol 0.1
beta-Dienoestrol
Dehydrostilbestrol
Dehydrostilboestrol
Dienestrol (125 mg)
DIENESTROL CRYSTALLINE
DIENESTROL VETRANAL, 250 MG
Dienestrol Solution, 100ppm
Di(p-oxyphenyl)-2,4-hexadiene
di(para-oxyphenyl)-2,4-hexadiene
3,4-DI(P-OXYPHENYL)-2 4-HEXADIENE
4,4’-(diethylideneethylene)di-pheno
4,4'-(DIETHYLIDENEETHYLENE)DIPHENOL
p,p'-(Diethylideneethylene)diphenol
p,p’-(diethylideneethylene)diphenol
3,4-bis(4-hydroxyphenyl)-4-hexadiene
3,4-DI(P-OXYPHENYL)-2 4-HEXADIENE 99%
4,4'-(2,4-Hexadiene-3,4-diyl)bisphenol
Phenol, 4,4'-(diethylideneethylene)di-
3,4-BIS(4-HYDROXYPHENYL)-2,4-HEXADIENE
3 4-BIS(P-HYDROXYPHENYL)-2 4-HEXADIENE
2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)-
3,4-bis(para-hydroxyphenyl)-2,4-hexadiene
para,para’-(diethylideneethylene)diphenol
3 4-BIS(P-HYDROXYPHENYL)-2 4-HEXADIENE 99%
4,4′-Dihydroxy-γ,δ-diphenyl-β,δ-hexadiene
4 4-DIHYDROXY-G D-DIPHENYL-B D-HEXADIENE 99%
4,4'-(1,2-Diethylidene-1,2-ethanediyl)bisphenol
4,4’-(1,2-diethylidene-1,2-ethanediyl)bis-pheno
4,4’-(1,2-diethylidene-1,2-ethanediyl)bisphenol
Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-
4,4’-hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene
4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene
4,4'-DIHYDROXY-GAMMA,DELTA-DIPHENYL-BETA,DELTA-HEXADIENE
Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-, (E,E)- | [EINECS(EC#)]
201-519-7 | [Molecular Formula]
C18H18O2 | [MDL Number]
MFCD00050983 | [MOL File]
84-17-3.mol | [Molecular Weight]
266.33 |
| Chemical Properties | Back Directory | [Appearance]
Colorless, needles or powder; odorless. Soluble in alcohol; practically insoluble in water; sensitive to light. | [Melting point ]
229 °C | [Boiling point ]
349.54°C (rough estimate) | [density ]
1.184 g/cm3 | [refractive index ]
1.4800 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
9.21±0.15(Predicted) | [color ]
Pale Yellow to Pale Beige | [Water Solubility ]
3mg/L(37 ºC) | [Merck ]
3104 | [BRN ]
2053694 | [CAS DataBase Reference]
84-17-3 | [EPA Substance Registry System]
Dienestrol (84-17-3) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless, needles or powder; odorless. Soluble in alcohol; practically insoluble in water; sensitive to light. | [Uses]
estrogen | [Definition]
ChEBI: An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively. | [Originator]
Synestrol,Schering,US,1947
| [Manufacturing Process]
Preparation of γ,δ-Bis-(4-Hydroxylphenyl)-Hexane-γ,δ-Diol: A sodium amalgam is prepared containing 6 grams of sodium and 400 grams of mercury. The
amalgam is covered with a solution of 20 grams of 4-hydroxypropiophenone in
a mixture of 30 ml of 5 N sodium hydroxide solution and 220 ml of water and
the mixture is heated to 28°-30°C and stirred gently. The reduction is
accompanied by development of heat and the temperature of the solution
rises to 34°-35°C, and then falls slowly. After 5 hours the alkaline solution is
separated from the mercury and diluted with 3 or 4 times its volume of water,
when, in order to form the benzoyl derivatives of the products, the solution is
vigorously stirred, while it is being cooled, with 20 ml of benzoyl chloride, the
solution being kept at a temperature of 15°-20°C. When the reaction is
completed, the benzoyl derivatives are filtered off, washed with water and
recrystallized from a mixture of benzene and alcohol, when a product with a
melting point of 195°-215°C is obtained.
Preparation of Dienestrol: In order to obtain dienoestrol, 14.6 grams of dry
4,4'-dibenzoate are refluxed with a mixture of 40 ml of acetic anhydride and
40 ml acetylchloride by heating in an oil-bath at about 90°C for 6 hours after
which the bath temperature is increased to 120°C and heating continued for a
further 18 hours, after which time the evolution of hydrogen chloride
practically ceases. The mixture is allowed to cool for several hours and the
crystals which separate are filtered off and recrystallized from an alcoholbenzene mixture when the product melts at 210°-222°C. This product is
converted into dienoestrol by adding 10.8 grams of it to 100 ml of 10% (w/v)
alcoholic potassium hydroxide solution and then refluxing during 1 hour. After
dilution with 200 ml of water and filtration from a small amount of insoluble
material, dienoestrol is precipitated from the alkaline solution by treatment
with carbon dioxide. It is filtered off, washed with water and recrystallized
from dilute alcohol after which it melts at 233°-234°C according to US Patent
2,464,203. | [Brand name]
Avc/dienestrol;Crinohermal fem;D.v.;Dienostrol cream;Dienstrogen;Dinol;Dufemine;Foragynol;Frein;Klianyi forte;Klianyl;Neo-oestrogenine;Ortho (cream);Ortho dienestrol cream. | [Therapeutic Function]
Estrogen | [World Health Organization (WHO)]
Dienestrol is a stilbene derivative. See WHO comment for
diethylstilbestrol. Vaginal forms of dienestrol, which were introduced in 1947, are
currently available in over 35 countries for the management of hypoestrogenic
vaginal atrophy.
(Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T | [Risk Statements ]
40-48-62-45 | [Safety Statements ]
22-24/25-45-36/37-53 | [WGK Germany ]
3
| [RTECS ]
SL0580000
| [HS Code ]
2907.29.0500 | [Safety Profile]
Suspected human
carcinogen. Human mutation data reported.
Experimental reproductive effects. Used as a
drug for the treatment of postmenopausal
symptoms. When heated to decomposition
it emits acrid smoke and irritating fumes. | [Hazardous Substances Data]
84-17-3(Hazardous Substances Data) |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|