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ChemicalBook--->CAS DataBase List--->824958-12-5

824958-12-5

824958-12-5 Structure

824958-12-5 Structure
IdentificationBack Directory
[Name]

LP 44
[CAS]

824958-12-5
[Synonyms]

LP 44
LP44 (hydrochloride)
4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamidehydrochlo
4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride
6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide:hydrochloride
[Molecular Formula]

C27H37N3OS.ClH
[MDL Number]

MFCD09971090
[MOL File]

824958-12-5.mol
[Molecular Weight]

488.136
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: >10mg/mL
[form ]

solid
[color ]

White to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

LP 44 Hydrochloride is used in the preparation of (tetrahydronaphthalenyl)arylpiperazinealkylamides which an agonist of the serotonin 5-HT7 receptor.
[Biological Activity]

High affinity 5-HT 7 receptor agonist (K i = 0.22 nM) that displays selectivity over 5-HT 1A and 5-HT 2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC 50 = 2.56 μ M).
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