| Identification | Back Directory | [Name]
LINOLEIC ACID SODIUM SALT | [CAS]
822-17-3 | [Synonyms]
SODIUM LINOLEATE
SodiumLinoleate>
linoleic acid sodium
LINOLEIC ACID SODIUM SALT
12-octadecadienoicacid(z,z)-sodiumsalt
sodium (9Z,12Z)-octadeca-9,12-dienoate
(Z,Z)-9,12-Octadecadienoic acid sodium salt
CIS-9,CIS-12-OCTADECADIENOIC ACID SODIUM SALT
LINOLEIC ACID SODIUM SALT ISO 9001：2015 REACH
(9Z,12Z)-9,12-Octadecadienoic acid sodium salt
Linoleic acid sodium salt,cis-9,cis-12-Octadecadienoic acid sodium salt | [EINECS(EC#)]
212-491-0 | [Molecular Formula]
C18H31NaO2 | [MDL Number]
MFCD00063202 | [MOL File]
822-17-3.mol | [Molecular Weight]
302.43 |
| Hazard Information | Back Directory | [Uses]
Linoleic Acid Sodium Salt can be used for cell culture materials, fluidic device module, drug testing, and fluidic device | [Biological Activity]
Linoleic acidas a component of acylglycosyl ceramidesplays a physiological role in maintaining the water permeability barrier of the skin. The deficiency of linoleic acid may cause poor growth or developmentscaly dermatitisand an impaired immune response in infants. It is used in cosmetic and personal care products. Linoleic acid is mainly used as emollients or moisturizers for skinnailsand hair. | [in vivo]
Linoleate (in the form of high-linoleate safflower oil, 10% (w/w), p.o., dietary, 4 weeks) sodium preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart[3].
Linoleate (in the form of a diet containing 15% (w/w) safflower oil; p.o., through diet) sodium reduces the induction of fatty acid synthetase activity in rat liver[4].
Linoleate (in the form of linoleate-enriched safflower oil, 100 ppm, dietary) sodium increases arachidonic acid (20:4n-6) levels in the serum of mice with antigen-induced antibodies and allergic reactions[5].
Linoleate (in the form of linoleate-enriched safflower oil, corresponding to an 18:2n-6/18:3n-3 ratio of 127; dietary) sodium attenuates gastric mucosal damage induced by ethanol, ischemia/reperfusion, and water immersion stress in a rat experimental gastric ulcer model[6].
Linoleate sodium (1 mg/mouse; ip; 1 time) significantly increases the median survival of mice inoculated with EAT cells from 18 days to 48 days, and completely inhibited tumor growth in more than 40% of mice[7].
Linoleate (in the form of linoleate-rich safflower oil, 10% of the semi-purified diet; fed) sodium makes ICR mice more sensitive to pentobarbital, as manifested by a shorter onset of anesthetic effect and a longer duration of anesthetic[8].
Linoleate (in the form of linoleate-rich safflower oil corresponding to an 18:2n-6/18:3n-3 ratio of less than 0.1; fed) can reduce urine protein levels, plasma urea nitrogen levels, glomerular crescent formation, and fibrinoid necrosis in rats with crescent-type anti-glomerular basement membrane nephritis, while increasing the proportion of arachidonic acid (20:4n-6) in glomerular phospholipids[9].
| Animal Model: | Male lean SHHF rats; spontaneously hypertensive heart failure model[3] | | Dosage: | High-linoleate safflower oil (HLSO), 10% (w/w) | | Administration: | ad libitum for 4 weeks | | Result: | Preserved L4CL and total CL to 90% of non-failing levels.
Attenuated 17-22% decreases in state 3 mitochondrial respiration.
Increased left ventricular fractional shortening significantly, and decreased plasma insulin levels.
Augmented the production of several eicosanoid species in serum compared with the control and lard groups.
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| [IC 50]
IL-8 |
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