| Identification | Back Directory | [Name]
R-(+)-DIOA | [CAS]
81166-47-4 | [Synonyms]
R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid | [Molecular Formula]
C20H24Cl2O4 | [MDL Number]
MFCD00069261 | [MOL File]
81166-47-4.mol | [Molecular Weight]
399.31 |
| Hazard Information | Back Directory | [Uses]
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
| [Uses]
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system. | [Biochem/physiol Actions]
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system. |
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