| Identification | Back Directory | [Name]
4-(Borono-10B)-L-phenylalanine | [CAS]
80994-59-8 | [Synonyms]
80994-59-8
Borofalan (10B)
Boronophenylalanine B-10
Acetylcysteine Impurity 35
L-4-[10B]Boronophenylalanine
L-Phenylalanine,4-(borono-10B)
10BenrichedL-4-boronophenylalanine,GMPBPA | [MDL Number]
MFCD02683190 |
| Chemical Properties | Back Directory | [Melting point ]
285-298 °C (decomp)(Solv: water (7732-18-5)) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Insoluble;Ethanol: Insoluble | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Description]
Boronophenylalanine B-10 is a boronophenylalanine and boron (boron-10) carrier for boron neutron capture therapy (BNCT) with potential anti-tumour activity. Upon administration, boron flange (10B) is mainly taken up by tumour cells. When irradiated with neutrons, boron flange (10B) absorbs neutrons and self-destructs, releasing short-range alpha radiation and "recoil" lithium in the tumour cells, leading to alpha radiation-induced tumour cell death. This highly selective local radio-targeting of tumour cells spares adjacent normal tissue. | [storage]
Store at -20°C |
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