| Identification | Back Directory | [Name]
PYRETHRINS | [CAS]
8003-34-7 | [Synonyms]
buhach
pyronyl
firmotox
CHECKOUT
pyrenone
pyrethre
PYRETHRUM
PYRETHRINS
WOPROTHRUM
PYRETHRIMS
pyrethrines
insectpowder
cineriniorii
jasmoliniorii
pyrethriniorii
triesteflowers
Pyrethrins (te
Pyrethrins (ISO)
PYRETHRUM-EXTRACT
Nature Pyrethrins
persianinsectpowder
dalmatianinsectpowder
dalmationinsectflowers
PYRETHRUM, 100MG, NEAT
pyrethrum(insecticide)
Pyrethrins (technical)
Pyrethrum(mixedisomers)
PTEROSTILBENE(FG)(CALL)
insecticides,pyrethrins
prentoxpyrethrumextract
pyrethrinsandpyrethroids
pyrethrumpowderotherthan
Pyrethrum 100mg [8003-34-7]
pyrethrins (bsi,iso,esa,jmaf)
chrysanthemumcinerareaefolium
pyrethrins, including cinerins
pyrethrumpowderotherthanpyrethrins
PYRETHRINS TECHNICAL MIXTURE, PESTANAL,
PYRETHRINS STANDARD, 50 - 60% IN ISOPARAFFIN
commercial product 57% mixed isomers (71:21:7)
PYRETHRUM-EXTRACT, ~25% PYRETHRINE I + P YRETHRIN II
(1R,3R)-2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (S)-2-methyl-4-oxo-3-(2,4-pentadienyl)-2-cyclopenten-1-yl
(1R,3R)-2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (S)-2-methyl-4-oxo-3-(2,4-pentadienyl)-2-cyclopenten-1-yl ester | [EINECS(EC#)]
232-919-8 | [Molecular Formula]
C43H56O8 | [MDL Number]
MFCD00078611 | [MOL File]
8003-34-7.mol | [Molecular Weight]
700.9 |
| Chemical Properties | Back Directory | [Description]
Pyrethrins/Pyrethrum are natural insecticides produced by certain Chrysanthemum species
of plants. In contrast, Permethrin (‘per-meth-rin’) is a synthetic, man-made insecticide,
whose chemical structure is based on natural pyrethrum. Pyrethrum was first recognised
as having insecticidal properties around 1800 in Asia and was used to kill ticks and
various insects such as fleas and mosquitoes. Six individual chemicals have active insecticidal
properties in the pyrethrum extract, and these compounds are called pyrethrins.
Pyrethrum are viscous, tan-coloured brown resins, liquids, or solids which inactivate
readily in air. Pyrethrum are soluble in organic solvents such as alcohol, kerosene, nitromethane,
petroleum ether, carbon tetrachloride, and ethylene dichloride. A quick acting
liquid insecticide especially suited for control of insect pests of vegetables, ornamentals,
and exotic crops. The piperonyl butoxide ingredient is used to enhance the activity of the
permethrin (synergist).
Pyrethrum has been used effectively to control insects for decades and is nonpersistent,
decomposing rapidly in the environment. This rapid degradation of pyrethrum has
resulted in little known cases of insect resistance, making it an excellent choice for the
control of agricultural pests, control of insects on pets and/or livestock. Pyrethrum powder
is toxic to ants, roaches, silverfish, bed bugs, fleas, wasps, spiders, crickets, mosquitoes,
and just about every other category of unwanted house or garden pest. Because it
decomposes rapidly in the environment, pyrethrum has been approved for a wide range
of indoor and outdoor uses, including homes, restaurants, broad-scale spraying operations,
and organic farms.
Pyrethrins break down quickly in the environment, especially when exposed to natural
sunlight. Pyrethroids are manufactured chemicals that are very similar in structure to the
pyrethrins, but are often more toxic to insects, as well as to mammals, and last longer in
the environment than pyrethrins. Pyrethrins and pyrethroids are often combined commercially
with other chemicals called synergists, which enhance the insecticidal activity
of the pyrethrins and pyrethroids. The synergists prevent some enzymes from breaking
down the pyrethrins and pyrethroids, thus increasing their toxicity. Technical-grade
(concentrated) pyrethrins and pyrethroids are usually mixed with carriers or solvents to
produce a commercial-grade formulated product. | [Definition]
Pyrethrolone ester of
chrysanthemummonocarboxylic acid. Most potent
insecticidal ingredient of pyrethrum flowers.
| [Appearance]
Pyrethrum is a variable mixture of compounds
which are found in cinerin, jasmolin, and pyrethrin.
Pyrethrum is a brown, viscous oil or solid. | [density ]
0.84-0.86 g/cm3 | [vapor pressure ]
2.7×10-3 (pyrethrin I) and 5.3×10-5
(pyrethrin II) Pa | [refractive index ]
n20/D 1.45
| [Fp ]
75 °C | [storage temp. ]
2-8°C
| [solubility ]
Chloroform: Slightly Soluble; Methanol: Slightly Soluble | [form ]
neat | [Water Solubility ]
0.2 (pyrethrin I) and 9 (pyrethrin II) mg l-1
(ambient temp.) | [Stability:]
Light Sensitive | [InChIKey]
VXSIXFKKSNGRRO-YWUDCVDHSA-N | [Uses]
Household insecticide (flies, mosquitoes, gar-
den insects, etc.).
| [EPA Substance Registry System]
Pyrethrins (8003-34-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
20/21/22-50/53 | [Safety Statements ]
13-60-61 | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
UR4200000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Hazardous Substances Data]
8003-34-7(Hazardous Substances Data) | [Toxicity]
The six insecticidal constituents of the extract of
the pyrethrum flowers Pyrethrum (Chrysanthemum cinerariaefolium). Pyrethrins I and II are most prominent, existing in the ratio 71:21:7 for pyrethrin (I and II), cinerin (I and II), jasmolin (I and II). Pyrethrins are potent, nonsystemic, contact insec_x0002_ticides, causing rapid paralysis or knockdown and death at a
later stage in a variety of insects. They exhibit low vertebrate
toxicity with an acute oral LD50 in rats of 1.2 g/kg. The mechanism of action involves modification of nerve membrane Na1
channels. Opening and closing of the Na1 channel is slowed,
resulting in increased Na1 permeability and depolarization
leading to hyperexcitability. Symptoms in humans include gastrointestinal irritation, nausea, vomiting, diarrhea, numbness of
tongue and lips, syncope, hyperexcitability, incoordination,
convulsions, muscular paralysis, collapse and death due to
respiratory paralysis. Treatment involves gastric lavage, emetics, cathartics, demulcents, artificial respiration if necessary
and short-acting barbiturates for convulsions. | [IDLA]
5,000 mg/m3 |
| Hazard Information | Back Directory | [General Description]
Colorless to white liquids (or tan dusts). Primarily a threat to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrate the soil, contaminate groundwater or nearby waterways. Toxic by inhalation, skin absorption and/or ingestion. Used as pesticide. Practically insoluble in water. | [Air & Water Reactions]
Oxidize relatively rapidly in air. Water emulsifiable. | [Reactivity Profile]
PYRETHRINS decompose rapidly in base; may generate heat with caustic solutions. May also react with acids to liberate heat. Generate flammable hydrogen with alkali metals and hydrides. | [Fire Hazard]
Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. | [Hazard]
Toxic by ingestion and inhalation.
| [Potential Exposure]
Pyrethrins are used as an ingredient of
various contact insecticides. Those engaged in the isolation,
formulation, or application of these materials. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, includ-
ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi-
cal attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. | [Shipping]
UN2902 Pesticides, liquid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explo-
sions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Compounds of the car-
boxyl group react with all bases, both inorganic and
organic (i.e., amines) releasing substantial heat, water and a
salt that may be harmful. Incompatible with arsenic com-
pounds (releases hydrogen cyanide gas), diazo compounds,
dithiocarbamates, isocyanates, mercaptans, nitrides, and
sulfides (releasing heat, toxic and possibly flammable
gases), thiosulfates and dithionites (releasing hydrogen sul-
fate and oxides of sulfur). | [Chemical Properties]
Pyrethrum , derived from extracts of the Chrysanthemum cinerariaefolinum plant, is a combination of six pyrethrin isomers, namely, pyrethrin 1, pyrethrin 2, cinerin 1, cinerin 2, jasmolin 1, and jasmolin 2. Pyrethroids are synthetically derived commercial compounds similar to pyrethrum. Pyrethrins and pyrethriods are insoluble in water and have a low vapor pressure. Pyrethrum is subject to photodegradation and is oxidized rapidly in the presence of air (U.S. EPA, 2006c; ATSDR, 2003). | [Chemical Properties]
Pyrethrum is a brown, viscous oil or solid. Oxidizes readily in air. Insoluble in water; soluble in other common sol- vents. Incompatible with alkalies. | [Indications]
Pyrethrins, rapid-acting compounds, derived from chrysanthemum plants, are
the leading over-the-counter louse remedy. These compounds interfere with
neural transmission, leading to paralysis and death. Piperonyl butoxide (PBO)
potentiates the pyrethrins by inhibiting the hydrolytic enzymes responsible for
pyrethrin metabolism in arthropods.
| [Health Hazard]
Pyrethrum dust causes dermatitis
and occasionally sensitization.The primary effect in humans from exposure
to pyrethrum is dermatitis. The usual
lesion is a mild erythematous dermatitis with
vesicles, papules in moist areas, and intense
pruritis; a bullous dermatitis may develop.
Some persons exhibit sensitivity similar to
pollinosis, with sneezing, nasal discharge, and
nasal stuffiness.2 A few cases of asthma due to
pyrethrum mixtures have been reported; some
of the people involved had a previous history
of asthma with allergy to a wide spectrum of
substances. | [Pharmacology]
The chrysanthemates
(pyrethrin I, cinerin I, and jasmolin I) are generally
more potent for insecticidal kill, whereas the
pyrethrates (pyrethin II, cinerin II, and jasmolin II) cause
more rapid knockdown. When combined with synergists,
the pyrethrins are effective at low doses in causing knockdown
and kill of a wide variety of pests. Pyrethrins exert
their effects primarily by acting on sodium channels in
nerves to disturb nerve conductance . Two distinct
effects, referred to as type I and type II, have been defined
for pyrethrins. | [Clinical Use]
Because of the high cost and rapid degradation of the pyrethrins, they usually are combined with piperonyI butoxide, a synergist. PiperonyI butoxide has no insecticidal activity in it own right but is thought to inhibit the cytochrome P450 enzyme of the insect, thus preventing an oxidative inactivation of the pyrethrins by the parasite. The combination is used in a 10:1 ratio of . piperonyl butoxide to pyrethrins. The mixture is used for treatment of Pedicul us humanus capitis, Pediculus humanus corporis, and Phthir'us pubis. Various dosage forms are available, including a gel, shampoo, and topical solution. | [Environmental Fate]
If released to air, the relatively low vapor pressure indicates that the pyrethrins and pyrethroids will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase compounds are rapidly degraded by direct photolysis and by reaction with photochemically produced hydroxyl radicals and ozone; the half-lives for these reactions in air are estimated to be 1.3 h and 17 min, respectively. Particulates may travel long distances and are removed from the atmosphere by wet or dry deposition (HSDB, 2013; ATSDR, 2003). Pyrethrins and pyrethroids are strongly adsorbed to the soil surfaces so they are not expected to be mobile. The compounds also strongly adsorb to suspended solids and sediment in the water column. Thus, partitioning to solids attenuates volatilization from soil and water surfaces. Pyrethrins and pyrethroids are often used indoors in sprays or aerosol bombs, and the volatilization rates from glass or floor surfaces may be significantly faster than from soils since these compounds are not likely to adsorb as strongly to these surfaces (ATSDR, 2003). These insecticides are readily biodegraded by microorganisms.
Pyrethrins and pyrethroids bioconcentrate in aquatic organisms, including fish, oysters, and insects. The bioconcentration factor for several commercial products in three species of fish ranged from 180 to 1200 depending on the amount of dissolved organic matter in the water column (ATSDR, 2003). | [Metabolic pathway]
Each year about 200,000 kg of pyrethrins are used as a crop insecticide,
much of it in enclosed conditions, and in public and animal health. Its
effectiveness outdoors is limited by the high photo-instability of its components.
This factor, and the great complexity of the mixture, has limited
studies on its metabolic fate. The environmental fate of pyrethrum has
been the subject of an excellent review by Crosby (1995). He points out
that, in spite of its still quite wide use, the environmental fate of its components
is largely unknown. The review deals with transport processes
(partitioning, volatilisation, adsorption, etc.), photochemical and chemical
degradation and environmental biotransformation (soil and water) as
predicted from the limited amount of data on the pure components and
that obtained for the closely related synthetic analogues, e.g. the
allethrins, phenothrin and the resmethrins. This is a valuable paper by
one of the foremost scientists in the field. The fates of the chrysanthemic
acid moiety and of the synthetic alcohol moieties of similar structure to
those in the natural pyrethrins (e.g. allethrolone) are considered to be
useful models for the fate of pyrethrin. The pyrethrin I series (chrysanthemate
esters) appears to have higher partition coefficients, bioconcentration
factors, volatility and soil adsorption, but lower aqueous solubility
than does the pyrethrin II series (pyrethrate esters). This suggests that
pyrethrin I (PI), cinerin I (CI) and jasmolin I (JI) may be more readily
transported in the environment.
Photodegradation and biotransformation should be very rapid for both
series. The limited experimental evidence given below supports these
predictions.
The best mformation is available for animals and most of the infomation
given below is derived from in vitro studies using rodent liver microsomes.
The constituents of pyrethrum appear to differ from the synthetic
pyrethroids in being relatively resistant to metabolic hydrolysis. Metabolism
is mainly via hydroxylation and elimination after conjugation. | [Degradation]
Pyrethrum is stable for years in the dark at ambient temperature. In light,
rapid photo-oxidation occurs with a DT50 in sunlight of ﹤15 minutes.
Hydrolysis to the component acids and alcohols occurs under basic
conditions.
Exposure to sunlight (Ruzo, 1982) affords a complex mixture of
products which is insecticidally inactive. Reactions include isomerisation,
hydrolysis and oxidation. Products derived from the photomodification
of the chrysanthemic acid moiety of pyrethrin I (PI) (Chen
and Casida, 1969) include the analogues of those described under phenothrin. Simultaneous reactions at the alcohol moieties lead to very
complex mixtures of products. | [Toxicity evaluation]
The pyrethrins have low toxicity to
mammals, and death after exposure to pyrethrins is rare.
Their lability in light and air leads to a lack of residual
activity and the need for repeated applications. This has
restricted the use of the natural pyrethrins in the animal
health sector. |
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