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ChemicalBook--->CAS DataBase List--->77928-71-3

77928-71-3

77928-71-3 Structure

77928-71-3 Structure
IdentificationBack Directory
[Name]

N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]-acetamide-bis-dihydrochloride (9CI)
[CAS]

77928-71-3
[Synonyms]

DIACETYLSPERMINE
N',N''-diacetylspermine
N1,N12-Diacetylspermine hydrochloride
N1,N12-Diacetylspermine Dihydrochloride
N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis-acetamide, dihydrochloride
[Molecular Formula]

C14H31ClN4O2
[MDL Number]

MFCD34469696
[MOL File]

77928-71-3.mol
[Molecular Weight]

322.88
Chemical PropertiesBack Directory
[Melting point ]

240-242oC
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Description]

N1,N12-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.
[Uses]

N1,N12-Diacetylspermine Dihydrochloride is a diacetylated derivative of Spermine (S680510) and is recognized as a novel tumor marker in patients with breast and colorectal cancers.
[Definition]

ChEBI: Diacetylspermine is a member of acetamides.
[storage]

Store at -20°C
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