| Identification | Back Directory | [Name]
1-(6-nitropyridin-3-yl)piperazine | [CAS]
775288-71-6 | [Synonyms]
AKOS BBV-002250
OTAVA-BB 1314167
1-(6-Nitro-3-pyridyl)piperazine
1-(6-Nitro-3-pyridinyl)piperazine
1-(6-nitropyridin-3-yl)piperazine
Piperazine, 1-(6-nitro-3-pyridinyl)- | [Molecular Formula]
C9H12N4O2 | [MDL Number]
MFCD09041112 | [MOL File]
775288-71-6.mol | [Molecular Weight]
208.22 |
| Chemical Properties | Back Directory | [Boiling point ]
422.8±40.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform; Methanol | [form ]
Solid | [pka]
8.50±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. |
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