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ChemicalBook--->CAS DataBase List--->771464-86-9

771464-86-9

771464-86-9 Structure

771464-86-9 Structure
IdentificationBack Directory
[Name]

1,11-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
[CAS]

771464-86-9
[Synonyms]

Plerixafor-3
Plerixafor Impurity G
Plerixafor Impurity 23
Plerixafor Impurity III
Plerixafor Impurity 3 HCl
PlerixaforImpurity3Dodecatrifluoroacetate
1,11-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-cyclotetradecane
Cyclotetradecane, 1,11-bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-
1,11-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
[Molecular Formula]

C46H84N12
[MOL File]

771464-86-9.mol
[Molecular Weight]

805.24
Hazard InformationBack Directory
[Uses]

1,11-Bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).
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