Identification | Back Directory | [Name]
CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID | [CAS]
74316-27-1 | [Synonyms]
cis-3-Amino-cyclobutaneca... 3-aminocyclobutane-1-carboxylic acid CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID cis-3-aminocyclobutane-1-carboxylic acid Cyclobutanecarboxylic acid, 3-amino-, cis- rel-(1R,3R)-3-aMinocyclobutane-1-carboxylic acid | [Molecular Formula]
C5H9NO2 | [MDL Number]
MFCD06659964 | [MOL File]
74316-27-1.mol | [Molecular Weight]
115.13 |
Hazard Information | Back Directory | [Uses]
CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
Azide 10a (0.30 g, 1.9 mmol) was dissolved in methanol (5 mL); then 6N HCl (2 mL) and 10% palladium on charcoal were added to the solution. The resulting mixture was stirred under 1 bar of hydrogen for 3 h, then the catalyst was filtered off, and the solvent was removed under reduced pressure. The residue was dissolvedin 6N HCl (5 mL) and refluxed upon stirring for 1 h, then evaporated in vacuum. The residue was purified by ion-exchange chromatography (Amberlite? IR-120(plus) ion-exchange resin, 3.5% aqueous ammonia as an eluent). cis-3-aminocyclobutanecarboxylic acid 1a as white powder, yield 0.16 g, 1.4 mmol, 71%. |
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