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ChemicalBook--->CAS DataBase List--->70396-18-8

70396-18-8

70396-18-8 Structure

70396-18-8 Structure
IdentificationBack Directory
[Name]

(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
[CAS]

70396-18-8
[Synonyms]

Boc-Val-Ala
Boc-L-Valyl- L-Alanin
N-Boc-L-valyl- L-alanine
(Tert-Butoxy)Carbonyl Val-Ala-OH
(tert-Butoxycarbonyl)-L-valyl-L-alanine
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]propanoic acid
[Molecular Formula]

C13H24N2O5
[MDL Number]

MFCD22381612
[MOL File]

70396-18-8.mol
[Molecular Weight]

288.34
Chemical PropertiesBack Directory
[Boiling point ]

493.3±30.0 °C(Predicted)
[density ]

1.121±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[form ]

Solid
[pka]

3.50±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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