| Identification | Back Directory | [Name]
JNJ 1661010 | [CAS]
681136-29-8 | [Synonyms]
CS-1527
Takeda-25
JNJ 1661010
JNJ 1661010, >=98%
JNJ 1661010 USP/EP/BP
TAKEDA-25;JNJ-1661010;JNJ 1661010
N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)- | [Molecular Formula]
C19H19N5OS | [MDL Number]
MFCD00209157 | [MOL File]
681136-29-8.mol | [Molecular Weight]
365.459 |
| Chemical Properties | Back Directory | [density ]
1.340±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥28mg/mL | [form ]
solid | [pka]
13.94±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models. | [Uses]
JNJ-1661010, is used to examine the contribution of endocannabinoid signaling in experimental fibrosis. In biological studies, this compound had shown to elevate the levels of arachidonoyl ethanolamide (AEA) in rat brains. | [Definition]
ChEBI: JNJ-1661010 is a N-arylpiperazine. | [Biological Activity]
Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC 50 = 12nM). Brain penetrant and active in vivo . | [storage]
Store at +4°C | [References]
1) Karbarz et al. (2009), Biochemical and biological properties of 4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase; Anesth. Analg., 108 316 |
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