| Identification | Back Directory | [Name]
BETHANECHOL | [CAS]
674-38-4 | [Synonyms]
BETHANECOL
Carbamyl-β-methylcholine
Carbamoyl-β-methylcholine
1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-
Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester) (8CI) | [EINECS(EC#)]
209-686-8 | [Molecular Formula]
C7H17N2O2+ | [MDL Number]
MFCD01669407 | [MOL File]
674-38-4.mol | [Molecular Weight]
161.22 |
| Hazard Information | Back Directory | [Uses]
Cholinergic. | [Definition]
ChEBI: The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-
esophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. | [Brand name]
Duvoid (WellSpring); Myotonachol (Glenwood);
Urecholine (Odyssey). | [in vivo]
Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion[4].
| Animal Model: | Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4] | | Dosage: | 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg). |
| [IC 50]
mAChR1; mAChR3; mAChR4; mAChR5 |
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