| Identification | Back Directory | [Name]
kaurenoic acid | [CAS]
6730-83-2 | [Synonyms]
NSC 339145
Cunabic acid
kaurenoic acid
Kauren-19-oic acid
ent-kaur-16-en-19-oicaci
ent-Kaur-16-en-19-oic acid
(-)-Kaur-16-en-18-oic acid
Kaurane-16-ene-18-oic acid
Kaur-16-en-18-oic acid,(4a)-
ent-Kaur-16(17)-en-19-oic acid
(4R,4aS,6aS,9R,11aR,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid | [Molecular Formula]
C20H30O2 | [MDL Number]
MFCD28978039 | [MOL File]
6730-83-2.mol | [Molecular Weight]
302.45 |
| Chemical Properties | Back Directory | [Melting point ]
171-172 °C | [Boiling point ]
426.6±34.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml | [form ]
A solid | [pka]
4.70±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.1,2,3 It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml.2 Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml).3 Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.1 | [Uses]
ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma. | [Definition]
ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity. |
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