| Identification | Back Directory | [Name]
Avermectin B1b | [CAS]
65195-56-4 | [Synonyms]
C-076B1b
AbaMectin B1b
avermectin b1b
Antibiotic C-076B1b
Abamectin B1b (~90%)
Ivermectin Impurity 2(Ivermectin EP Impurity B)
5-O-Demethyl-25-de(1-methylpropyl)-25-isopropylAvermectin A1a
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)- | [EINECS(EC#)]
265-611-9 | [Molecular Formula]
C47H70O14 | [MDL Number]
MFCD03701301 | [MOL File]
65195-56-4.mol | [Molecular Weight]
859.05 |
| Hazard Information | Back Directory | [Uses]
Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 25-position. In vitro and in vivo studies have shown this analogue to be active, but less potent than the B1a analogue | [Definition]
ChEBI: Avermectin B1b is an avermectin. | [Brand name]
(Merck)Avomec [Veterinary] (Merial); Bovitin
[Veterinary] (Merial); Doratect [Veterinary] (Merial);
Duomectin [Veterinary] (Merial); Duotin [Veterinary]
(Merial); Endecto (Merck); Enzec (Merck); Enzek
(Merck); Parafoil (Merck); Vertimil (Zectin
(Merck). | [Biological Activity]
avermectin b1 is a mixture of avermectins containing >80% avermectin b1a and <20% avermectin b1b. b1a and b1b have very similar biological and toxicological properties. | [in vitro]
the avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium. avermectin b1 is a natural fermentation product of this bacterium. | [in vivo]
avermectin b1 therapy resulted in significant decreases in mean strongyle egg after treatment. all horses given ivermectin or avermectin b1 had zero strongyle egg counts 14 and 28 d after treatment. the oral administration of avermectin b1 appeared to be highly efficacious against intestinal strongyles and onchocera microfilaria [1]. | [storage]
Store at -20°C | [References]
[1] mogg td, pollitt cc, willmore jp, thompson h. efficacy of avermectin b1 given orally against equine intestinal strongyles and onchocera microfilaria. aust vet j. 1990;67(11):399-401. |
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