| Identification | Back Directory | [Name]
PROGUANIL HYDROCHLORIDE | [CAS]
637-32-1 | [Synonyms]
m4888
3359rp
diguanyl
sn12,837
Paludrin
Chlorguanid
Chloroquanil
Proguanil HCL
ChlorguanideHCl
palusilhydrochloride
drinupalhydrochloride
guanatolhydrochloride
paludrinehydrochloride
PROGUANIL HYDROCHLORIDE
chlorguanidehydrochloride
chloroguanidehydrochloride
Chlorguanide Hydrochloride3
chloroguanidinehydrochloride
Proguanil Hydrochloride (200 mg)
N1-(4-Chlorophenyl)-N5-isopropylbiguanide
1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride
1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
n-4-chlorophenyl-n(sup5)-isopropyldiguanidehydrochloride
Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride
PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
IMidodicarboniMidic diaMide, N-(4-chlorophenyl)-N'-(1-Methylethyl) -, Hydrochloride (1:1) | [EINECS(EC#)]
211-283-7 | [Molecular Formula]
C11H17Cl2N5 | [MDL Number]
MFCD01732193 | [MOL File]
637-32-1.mol | [Molecular Weight]
290.19 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
249-2510C | [storage temp. ]
-20°C Freezer | [solubility ]
acetonitrile: water: ~1mg/mL (60/40) | [form ]
solid |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Antimalarial | [Uses]
Labeled Proguanil, intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry. | [Brand name]
Paludrine (Zeneca). | [General Description]
Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Biochem/physiol Actions]
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
3249 | [WGK Germany ]
3 | [RTECS ]
DU1750000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2925294500 | [Toxicity]
LD50 orally in rats: 200 mg/kg (Schmidt) |
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