| Identification | Back Directory | [Name]
8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid | [CAS]
634175-34-1 | [Synonyms]
ML328
8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid
Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-[4-[thioxo[[3-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- | [Molecular Formula]
C22H21F3N6O3S | [MOL File]
634175-34-1.mol | [Molecular Weight]
506.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (49.36 mM);Ethanol: Insoluble | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Biological Activity]
CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM. | [References]
[1] Bannister TD, et al. 2012 Dec 17 [updated 2013 Apr 5]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. |
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