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ChemicalBook--->CAS DataBase List--->62284-79-1

62284-79-1

62284-79-1 Structure

62284-79-1 Structure
IdentificationBack Directory
[Name]

(-)-4-BROMOTETRAMISOLE OXALATE
[CAS]

62284-79-1
[Synonyms]

R 30402
6-BROMOLEVAMISOLE OXALATE
L-P-BROMOTETRAMISOLE OXALATE
(-)-P-BROMOLEVAMISOLE OXALATE
(-)-P-BROMOTETRAMISOLE OXALATE
(-)-4-BROMOTETRAMISOLE OXALATE
L-(-)-P-BROMOTETRAMISOLE OXALATE
(S)-(-)-4-BROMOTETRAMISOLE OXALATE
(-)-P-BROMOTETRAMISOLE OXALATE SALT
(-)-4-bromotetramisole oxalate salt
L(-)-p-Bromotetramisole oxalate,99%
(-)-p-Bromotetramosole Oxalate Salt
(S)-6-(p-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
S(-)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE
(-)-(S)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE
6-(4-Bromophenyl)-2,3,5,6-tetrahydro-(6S)-imidazo[2,1-b]thiazole,ethanedioate (1:1)
(-)-6(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE ETHANEDIOATE OXALATE SALT
(-)-4-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, S(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
(-)-p-Bromotetramisole oxalate salt, 6-Bromolevamisole oxalate salt, (S)-(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate salt
[EINECS(EC#)]

263-487-0
[Molecular Formula]

C13H13BrN2O4S
[MDL Number]

MFCD00070406
[MOL File]

62284-79-1.mol
[Molecular Weight]

373.22
Chemical PropertiesBack Directory
[Appearance]

white to light yellow crystal powde
[Melting point ]

192 °C (dec.)
[Fp ]

87℃
[storage temp. ]

2-8°C
[solubility ]

Soluble in Water (up to 10 mg/ml)
[form ]

liquid
[color ]

White
[optical activity]

[α]25/D 104°, c = 0.5 in H2O
[BRN ]

4944883
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Hazard InformationBack Directory
[Chemical Properties]

white to light yellow crystal powde
[Description]

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.
[Uses]

L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.
[Biochem/physiol Actions]

(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.
[target]

alkaline phosphatase
[References]

1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515 2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108 3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

21/22-36/37/38-20/21/22
[Safety Statements ]

24/25-36/37/39-26
[WGK Germany ]

3
[F ]

10
Spectrum DetailBack Directory
[Spectrum Detail]

(-)-4-BROMOTETRAMISOLE OXALATE(62284-79-1)1HNMR
(-)-4-BROMOTETRAMISOLE OXALATE(62284-79-1)Raman
(-)-4-BROMOTETRAMISOLE OXALATE(62284-79-1)IR
(-)-4-BROMOTETRAMISOLE OXALATE(62284-79-1)FT-IR
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